DIY-HP-LED
Well-Known Member
I saw the story on the news, shocking. Something needs to be done about bullshit.
Pandemic 2020
- Thread starter Jimdamick
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Dr.Amber Trichome
Well-Known Member
I don’t know if there could be.? Have you ever heard that saying , you can’t fix stupid . Maybe better education and teaching kids in school about what has happened with this pandemic and Trump and discussions on brainwashing and cults might be helpful .
Dryxi
Well-Known Member
He says 4 years for life to go back to "normal" even with vaccines coming out. Mask mandates without enforcement are worthless and relying on people to just wear one out of the goodness of their hearts seems worthless too since people just don't wear them. Biden might be grappling with the pandemic his entire time in office.
www.pbs.org
Even with a vaccine, COVID-19 will last for years, expert says
While Dr. Anthony Fauci of the National Institutes of Health and other health experts are hopeful vaccines will make a real difference in managing COVID-19, some of the pandemic's challenges are likely to persist for a long time. Dr. Nicholas Christakis, a physician and sociologist at Yale...
www.pbs.org
DIY-HP-LED
Well-Known Member
The Moderna vaccine is 94% effective, is based on new mRNA technology and production is rapid and cheap, it can be stored in regular fridges and produces a high level of antibodies even in older people.He says 4 years for life to go back to "normal" even with vaccines coming out. Mask mandates without enforcement are worthless and relying on people to just wear one out of the goodness of their hearts seems worthless too since people just don't wear them. Biden might be grappling with the pandemic his entire time in office.
Even with a vaccine, COVID-19 will last for years, expert says
While Dr. Anthony Fauci of the National Institutes of Health and other health experts are hopeful vaccines will make a real difference in managing COVID-19, some of the pandemic's challenges are likely to persist for a long time. Dr. Nicholas Christakis, a physician and sociologist at Yale...
"By year's end, it expects to have 20 million doses of the vaccine ready to ship in the U.S., and it remains on track to manufacture 500 million to 1 billion doses globally next year".
This will knock it back considerably, other countries will be producing it under license as well, Canada has contracts with both companies. I believe the pandemic will be on it's last legs by summer in north America and antibody therapies will be available too and they confer temporary immunity, the vaccine should produce as much immunity as catching a severe case of covid, only you won't be fighting for your life and living in Hell while doing it. The social effects will take some time and healing, some economic effects are permanent.
This is very good news, we have a way out and a timeline, more importantly we have hope. Joe just got what he needed and it will be ready to go when he hits the WH, Joe is gonna be a hero.
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Covid-19 vaccine candidate 94.5 percent effective, Moderna says
"A vaccine for Covid is a real probability and ... having more than one supplier should help assure better and more equitable global availability," one expert said.
'Truly striking': Covid-19 vaccine candidate 94.5 percent effective, Moderna says
"A vaccine for Covid is a real probability and ... having more than one supplier should help assure better and more equitable global availability," one expert said.
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DIY-HP-LED
Well-Known Member
Perhaps not older people should get this vaccine first, but younger people, those who are more socially active and harder to control, they will need to get it before school season in the fall and I imagine the priority will be dependent on the infection rate. I'm sure they have a plan, with the most vulnerable getting it first, those most likely to land in a hospital and ICU. By summer with Joe running the show and a vaccine rolled out for over 6 months I imagine the infection rate will be manageable, but it would be nice to get the kids vaccinated by school season or during the beginning of it at the latest.
It looks like this Moderna vaccine is unusually effective in older people too, so if the vulnerable can be protected, older people and those ethic groups who are more vulnerable, then with antibody therapies, the mortality rate should be next to nothing by the end of summer. Back to whatever normal will be then, but we won't have covid on our backs any more.
It looks like this Moderna vaccine is unusually effective in older people too, so if the vulnerable can be protected, older people and those ethic groups who are more vulnerable, then with antibody therapies, the mortality rate should be next to nothing by the end of summer. Back to whatever normal will be then, but we won't have covid on our backs any more.
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Fogdog
Well-Known Member
Moderna tests were conducted with 30,000 people in the study. It's a pretty good sample size and enough to say that it is effective. Probably by as much as 90% effective. But other conclusions such as "works better in older people", it's too early to say something like that.
www.nytimes.com
What are the data that goes into this conclusion?
30,000 test subjects, all more that 18 years of age. Half were given a placebo in a blind randomized selection process..
The trial began in July.
During that time 95 people became sick due to covid.
90 of them were given the placebo
5 were given the vaccine.
Based upon these results, they claim 94.5% effective. People should assume it's not really 94.5% effective because, I mean, wow, that's pretty small number of positive results upon which to claim three significant figures in test accuracy. 90% is probably better. Of the 11 people who became really ill due to covid, none were given the vaccine.
Only an idiot would say from these tests that the vaccine is "unusually effective" for older people. Simply not enough data to support that. But there is enough data to say the vaccine is very effective and that it seems to be just as effective for older people as for younger. So, hooray, that's a good thing.
Moderna's Covid-19 Vaccine, Explained (Published 2020)
Does this mean the end of the pandemic? Who was in the trial? Is it part of Operation Warp Speed? And other questions answered.
What are the data that goes into this conclusion?
30,000 test subjects, all more that 18 years of age. Half were given a placebo in a blind randomized selection process..
The trial began in July.
During that time 95 people became sick due to covid.
90 of them were given the placebo
5 were given the vaccine.
Based upon these results, they claim 94.5% effective. People should assume it's not really 94.5% effective because, I mean, wow, that's pretty small number of positive results upon which to claim three significant figures in test accuracy. 90% is probably better. Of the 11 people who became really ill due to covid, none were given the vaccine.
Only an idiot would say from these tests that the vaccine is "unusually effective" for older people. Simply not enough data to support that. But there is enough data to say the vaccine is very effective and that it seems to be just as effective for older people as for younger. So, hooray, that's a good thing.
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DIY-HP-LED
Well-Known Member
From what I could gather in the interview with the chief scientist, he said a quarter of the people were over 65, most flu vaccines are much less effective in older people. This new technology uses mRNA to cause our cells to create the spike proteins only and our immune response is similar to a bad case of covid, like an older person might get.Moderna tests were conducted with 30,000 people in the study. It's a pretty good sample size and enough to say that it is effective. Probably by as much as 90% effective. But other conclusions such as "works better in older people", it's too early to say something like that.
Moderna's Covid-19 Vaccine, Explained (Published 2020)
Does this mean the end of the pandemic? Who was in the trial? Is it part of Operation Warp Speed? And other questions answered.
What are the data that goes into this conclusion?
30,000 test subjects, all more that 18 years of age. Half were given a placebo in a blind randomized selection process..
The trial began in July.
During that time 95 people became sick due to covid.
90 of them were given the placebo
5 were given the vaccine.
Based upon these results, they claim 94.5% effective. People should assume it's not really 94.5% effective because, I mean, wow, that's pretty small number of positive results upon which to claim three significant figures in test accuracy. 90% is probably better. Of the 11 people who became really ill due to covid, none were given the vaccine.
Only an idiot would say from these tests that the vaccine is "unusually effective" for older people. Simply not enough data to support that. But there is enough data to say the vaccine is very effective and that it seems to be just as effective for older people as for younger. So, hooray, that's a good thing.
We have no real data yet, nothing peer reviewed, just their word, but they did release more info than the other guys and had a better clinical trial result, thus far. The most exciting thing is they have this tough liposome that they package the mRNA strand in and it can stand room temps for 10 hours and just needs a regular freezer.
Naturally everything has to be taken with a grain of salt, but I expect Health Canada will be getting the data along with the FDA, we have a contract too. If you can't rely on the Trump FDA, perhaps health Canada can help temporarily. I think this one will be a winner and a game changer, Fauci is enthusiastic as are the other experts, so me too.
DIY-HP-LED
Well-Known Member
If they post the interview with chief scientist at Moderna on Youtube I'll post it, he gave a bit more info than was in the raw data they released which wasn't much.Moderna tests were conducted with 30,000 people in the study. It's a pretty good sample size and enough to say that it is effective. Probably by as much as 90% effective. But other conclusions such as "works better in older people", it's too early to say something like that.
Moderna's Covid-19 Vaccine, Explained (Published 2020)
Does this mean the end of the pandemic? Who was in the trial? Is it part of Operation Warp Speed? And other questions answered.
What are the data that goes into this conclusion?
30,000 test subjects, all more that 18 years of age. Half were given a placebo in a blind randomized selection process..
The trial began in July.
During that time 95 people became sick due to covid.
90 of them were given the placebo
5 were given the vaccine.
Based upon these results, they claim 94.5% effective. People should assume it's not really 94.5% effective because, I mean, wow, that's pretty small number of positive results upon which to claim three significant figures in test accuracy. 90% is probably better. Of the 11 people who became really ill due to covid, none were given the vaccine.
Only an idiot would say from these tests that the vaccine is "unusually effective" for older people. Simply not enough data to support that. But there is enough data to say the vaccine is very effective and that it seems to be just as effective for older people as for younger. So, hooray, that's a good thing.
captainmorgan
Well-Known Member
Covid-19 may never leave us and we may need a yearly vaccine.
DIY-HP-LED
Well-Known Member
Not the same interview I saw.
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Moderna chief scientist on promising new vaccine data
Moderna’s shares soared after the company said its potential vaccine to prevent Covid-19 produced a “robust” immune response in all 45 patients in its early stage human trial, according to newly released data published Tuesday evening in the peer-reviewed New England Journal of Medicine. Tal Zaks, Moderna chief medical officer, joins CNBC's Meg Tirrell and "Squawk Box" to discuss.
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Moderna chief scientist on promising new vaccine data
Moderna’s shares soared after the company said its potential vaccine to prevent Covid-19 produced a “robust” immune response in all 45 patients in its early stage human trial, according to newly released data published Tuesday evening in the peer-reviewed New England Journal of Medicine. Tal Zaks, Moderna chief medical officer, joins CNBC's Meg Tirrell and "Squawk Box" to discuss.
DIY-HP-LED
Well-Known Member
Add it to the annual flu shot, this is version 1, I'm sure they are working on version 2 as we speak.
DIY-HP-LED
Well-Known Member
This guy should know.
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Dr. Gottlieb on Moderna vaccine: We can effectively end Covid-19 pandemic in 2021
CNBC's "Squawk Box" team discusses progress on the coronavirus vaccine front. Moderna's mRNA vaccine was just announced to have a 94.5% efficacy rate. Dr. Scott Gottlieb, former FDA commissioner and board member of Illumina and Pfizer, discusses how it will affect the economic recovery and public health efforts.
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Dr. Gottlieb on Moderna vaccine: We can effectively end Covid-19 pandemic in 2021
CNBC's "Squawk Box" team discusses progress on the coronavirus vaccine front. Moderna's mRNA vaccine was just announced to have a 94.5% efficacy rate. Dr. Scott Gottlieb, former FDA commissioner and board member of Illumina and Pfizer, discusses how it will affect the economic recovery and public health efforts.
DIY-HP-LED
Well-Known Member
Fortunately covid does not mutate much, at least the part they are targeting with the latest mRNA vaccines and they work a bit differently than other vaccines.
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www.discovermagazine.com
Why Flu Vaccines Don’t Work as Well in the Elderly
The adage that “the older you are, the wiser you get” doesn’t always apply to our immune systems. Despite being exposed to a lifetime’s worth of illnesses, immune systems in the elderly are worse at fighting stealthy, shape-shifting viruses like the flu.
Why aging decreases our immune system’s abilities has been a mystery to researchers. But a new study published in Cell Host & Microbe finds that our infection-battling B-cells become blunted with age, making us less equipped to fight off the flu and other illnesses in our advanced years. And because most vaccines rely on a B-cell response to work, the finding may explain why the influenza vaccine is less effective in this population.
New Mutations, Old Tools
A research team compared how B-cells and antibodies from younger adults (ages 22 to 64) and elderly adults (ages 71 to 89) responded to vaccines for recent flu strains. The B-cells of younger people were good at recognizing mutations of the virus and producing protective antibodies. But the older people’s B-cells were less adept at fighting the rapidly changing influenza virus. Their B-cells were stagnant and the antibodies they produced were less diverse and less potent than the younger people’s.
“[Their B-cells] are ‘stuck in the past.’ The influenza viruses mutate and evolve with time, but with age, our B-cells can no longer keep up,” said senior study author Patrick Wilson, a researcher at the University of Chicago. “They don’t have quite the right tool to fight it.”
Our immune systems learn from exposure, and B-cells play a major role in the immunity process. With the help of other cells in the immune system, B-cells churn out antibodies when we get sick or receive an immunization. Antibodies are Y-shaped proteins that bind to harmful invaders and mark them for destruction. Once the infection is cleared, a type of record-keeping B-cell, known as memory B-cells, remain in the bloodstream and stand ready to produce antibodies if the threat is encountered again.
As we age, something hampers our immune system’s ability to produce ever-stronger antibodies in response to infections. As a result, older people are relying on mostly memory B-cells to make antibodies from long-past immune responses that are ill-equipped to squash rapidly evolving pathogens like the flu virus.
Immune Imprinting
While new flu strains threw the elderly participant’s B-cells for a loop, they were very proficient at combatting mutations of the virus that circulated during their childhoods. Young people’s B-cells, however, struggled when faced with older strains of the flu.
Although each person’s timeline is different, the strength of our immune response diminishes over time once we hit a certain age. The researchers observed that participants between 50 and 70-years-old had intermediate declines in their influenza-fighting power, with steeper drops typical after age 70.
That’s why vaccines are so necessary for the elderly. But because the ever-changing flu virus is capable of outsmarting young and old immune systems alike, even a well-matched vaccine may only reduce the chances of illness by 40 to 60 percent in the general population. Effective rates are typically less for the elderly, but Wilson stressed that “not as effective” does not mean “not at all effective.”
“Vaccination still helps even if not as effective with age,” he said. “With vaccination, the duration and severity of illness will be reduced, which is extremely important for older people as the severity of infection is already much worse.”
As the research community toils toward a universal flu vaccine that would provide lifetime immunity, there have been advancements in the interim. New high-dose flu vaccines for older adults are now available and can unleash more protective antibodies.
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Why Flu Vaccines Don’t Work as Well in the Elderly
Why Flu Vaccines Don’t Work as Well in the Elderly
www.discovermagazine.com
Why Flu Vaccines Don’t Work as Well in the Elderly
The adage that “the older you are, the wiser you get” doesn’t always apply to our immune systems. Despite being exposed to a lifetime’s worth of illnesses, immune systems in the elderly are worse at fighting stealthy, shape-shifting viruses like the flu.
Why aging decreases our immune system’s abilities has been a mystery to researchers. But a new study published in Cell Host & Microbe finds that our infection-battling B-cells become blunted with age, making us less equipped to fight off the flu and other illnesses in our advanced years. And because most vaccines rely on a B-cell response to work, the finding may explain why the influenza vaccine is less effective in this population.
New Mutations, Old Tools
A research team compared how B-cells and antibodies from younger adults (ages 22 to 64) and elderly adults (ages 71 to 89) responded to vaccines for recent flu strains. The B-cells of younger people were good at recognizing mutations of the virus and producing protective antibodies. But the older people’s B-cells were less adept at fighting the rapidly changing influenza virus. Their B-cells were stagnant and the antibodies they produced were less diverse and less potent than the younger people’s.
“[Their B-cells] are ‘stuck in the past.’ The influenza viruses mutate and evolve with time, but with age, our B-cells can no longer keep up,” said senior study author Patrick Wilson, a researcher at the University of Chicago. “They don’t have quite the right tool to fight it.”
Our immune systems learn from exposure, and B-cells play a major role in the immunity process. With the help of other cells in the immune system, B-cells churn out antibodies when we get sick or receive an immunization. Antibodies are Y-shaped proteins that bind to harmful invaders and mark them for destruction. Once the infection is cleared, a type of record-keeping B-cell, known as memory B-cells, remain in the bloodstream and stand ready to produce antibodies if the threat is encountered again.
As we age, something hampers our immune system’s ability to produce ever-stronger antibodies in response to infections. As a result, older people are relying on mostly memory B-cells to make antibodies from long-past immune responses that are ill-equipped to squash rapidly evolving pathogens like the flu virus.
Immune Imprinting
While new flu strains threw the elderly participant’s B-cells for a loop, they were very proficient at combatting mutations of the virus that circulated during their childhoods. Young people’s B-cells, however, struggled when faced with older strains of the flu.
Although each person’s timeline is different, the strength of our immune response diminishes over time once we hit a certain age. The researchers observed that participants between 50 and 70-years-old had intermediate declines in their influenza-fighting power, with steeper drops typical after age 70.
That’s why vaccines are so necessary for the elderly. But because the ever-changing flu virus is capable of outsmarting young and old immune systems alike, even a well-matched vaccine may only reduce the chances of illness by 40 to 60 percent in the general population. Effective rates are typically less for the elderly, but Wilson stressed that “not as effective” does not mean “not at all effective.”
“Vaccination still helps even if not as effective with age,” he said. “With vaccination, the duration and severity of illness will be reduced, which is extremely important for older people as the severity of infection is already much worse.”
As the research community toils toward a universal flu vaccine that would provide lifetime immunity, there have been advancements in the interim. New high-dose flu vaccines for older adults are now available and can unleash more protective antibodies.
Sativied
Well-Known Member
The reason the flu shot is yearly is partly because we import a slightly mutated version from China and elsewhere in asia every year, where weather conditions, dense populations, and poor treatment of animals, allow for an ongoing transmission. The most common flu strain, H3N2, originated from Hong Kong in 1968. The more recent swineflu from 2009, now part of the yearly flu vaccin, resulted in nearly 100k deaths since, and 1mil hospitalizations in the US alone. Swine flu v 2 was discovered in china earlier this year and has the potential of going global. as well.
The dominant SARS-CoV-2 virus type is already a mutated version, and tests have shown antibodies still work, and thus so will vaccins. Mutating doesn’t always mean new or reoccurring vaccin.
Assuming enough people will vaccinate to create herd immunity (yeah big assumption), it will definitely require a yearly shot IF there are untreated areas from which the virus is imported every year AND if the virus mutates so much it’s no longer recognized by antibodies. Neither of those conditions are a given, in which case a shot may be required only when traveling to/from certain areas. There’s still reason to be hopeful covid-19 will “leave us”.
It seems unlikely the rest of the world will continue to allow china to spread deadly and economically costly viruses unchecked, and if there’s any country that can force its citizens to vaccinate it’s china. On the other hand, this year they will double the amount of flu shots, from 25mil to 50mil, which is nothing (little over 4%) on their total population.
“China virus” isn’t xenophobic or racist, it’s just not specific enough. Which fucking china virus... the world is still in panic mode, but some day soon the world needs to have a talk with china. About how they treat their animals for example.
The dominant SARS-CoV-2 virus type is already a mutated version, and tests have shown antibodies still work, and thus so will vaccins. Mutating doesn’t always mean new or reoccurring vaccin.
Assuming enough people will vaccinate to create herd immunity (yeah big assumption), it will definitely require a yearly shot IF there are untreated areas from which the virus is imported every year AND if the virus mutates so much it’s no longer recognized by antibodies. Neither of those conditions are a given, in which case a shot may be required only when traveling to/from certain areas. There’s still reason to be hopeful covid-19 will “leave us”.
It seems unlikely the rest of the world will continue to allow china to spread deadly and economically costly viruses unchecked, and if there’s any country that can force its citizens to vaccinate it’s china. On the other hand, this year they will double the amount of flu shots, from 25mil to 50mil, which is nothing (little over 4%) on their total population.
“China virus” isn’t xenophobic or racist, it’s just not specific enough. Which fucking china virus... the world is still in panic mode, but some day soon the world needs to have a talk with china. About how they treat their animals for example.
DIY-HP-LED
Well-Known Member
In Canada we ordered 10 doses of various vaccine candidates, including the 2 recently in the news, for every citizen, the unused ones will end up in other poorer countries. This is not a static situation, but a dynamic one, there will be other vaccines and treatments for this pandemic. We had a vaccine in months for this disease, a lot of time was spent safety testing and clinical trials. We will be ready for the next pandemic and many of the tools for dealing with it quickly are being developed now. Pandemic prevention and mitigation will receive military level priority, not just in America either. In 5 years we will be much better at dealing with viral infections.
Donald made a crises that would be a challenge for any government into a catastrophe and we all know the reasons and results. America has 8.6 times the US population and we are the closest model to America, we have 300,000 total cases, in American terms about 2.6 million cases, America under Trump has over 11,000,000 cases, almost four and a half times as many per capita than Canada. At least 9 million cases can be placed at Trump's feet. Our response was average for an industrialized nation, below average in the beginning I figure.
Lucky Luke
Well-Known Member
Sir Napsalot
Well-Known Member
Having strong body odor helps keep people at bay
DIY-HP-LED
Well-Known Member
Joe's people are turning up the heat on Donald and the head of the GSA, she will be fired hours after signing the papers and on Jan 20th any way. I don't think the democrats are putting the heat on her too much yet, every day the transition is delayed hurts the republicans in Georgia, it's in no way their fault though. When they feel it might start costing lives, especially since the announcement of two vaccine candidates, the heat will be turned up as it recently has. Joe's experts want in on the vaccine data, the production logistics and distribution plan, access to everything else goes along with it. After Dec 14th Joe becomes president elect legally and constitutionally, if Donald isn't transitioning by then on at least the public health end, I don't see him lasting his term. He would cost them 2 senate seats Georgia (all they care about) and either the 25th or impeachment would move forward, too many lives would be on the line not to.
Their main problem is they would have to explain things to Joe's people, who are old hands, they don't have an explanation, nobody does, not even Donald. You will see over the next year how bad a half staffed shit show of an administration he used to run the country into the ground. The DOJ transition will be interesting, if it happens at all, if Bill Barr isn't called a cocksucker to his face by the new AG, I'd be surprised.
captainmorgan
Well-Known Member
Researchers Identify Melatonin as Possible COVID-19 Treatment
A new study suggests that one potential treatment for the virus could be found at your local pharmacy: the common sleep aid melatonin.
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