@SirChongalong: no reason whatsoever you can't smoke the first batch. The toxicity of colchicine (especially miniscule doses only used when first starting a seed) has been greatly overstated here. As other people have pointed out, it's actually a drug used in human medicine (primarily for the treatment of gout, but potentially for other things). For any substance (including water, oxygen, and sugar-- all vital elements of life) the dose makes the poison.
@elfroggo: If you've ever eaten a large 'modern' piece of fruit (be it a large strawberry, apple, or what have you), then you've had a genetically modified fruit whose ancestors came from genetic manipulation with colchicine. There's plenty of reason to be wary of GMO stuff where they're introducing new genes/proteins that our bodies might potentially have allergic reactions to. In most cases it's probably not a big deal, but without a lot of experimenting it would be tough to know for sure. OTOH, making something polyploidal doesn't change the identity of the genes in each cell, it just increases their number. The net effect is that individual cells may take a little bit longer to grow (longer time spent in S1 phase) than they would otherwise, but the individual cells (and the organism) will be bigger. The main reason it might be 'healthier' is that individual cells are very unlikely to suffer a loss-of-function mutation. In short... with regard to your fears of polyploidy... ...get over it.