I can't think of anything you can do to adapt until federal decriminalization -- at which point you can sell across state lines to other legal states. But you'd need to be commercial to take advantage of that most likely. They'll want to see your license and CoA/lab tests.
Life is good still in the illegal/medical states. I don't grow a lot, maybe 6 pounds per year but I can always sell my excess easily through a few contacts. Still getting $250-$300/zip which isn't too bad for some secondary income.
As far as Sativas go, we're going to be seeing less and less of the Indica/Sativa duality as the science is moving towards chemovars rather than cultivars. There are Sativa cultivars with similar chemical profiles to Indicas and vice versa which from a medical standpoint, could make Sativas not even worth growing except for cultivator use.
You have to remember, the average person who walks into a dispensary is a moron. They don't hang out on cannabis forums, read white papers on cannabis or watch grow videos. Imagine you back in high school buying dime bags and the extent of your knowledge was not to smoke seeds and stems. These days it's the same except now there are numbers on all of the labels and that's all the average user cares about. If they see a strain that's $30 for 1/8th of 25% vs. $45 for 1/8th of 19%, which do you think they'll buy? The latter could be straight fire rip your head off herb and the former grown outdoor and sprayed with all kinds of "organic" shit and sat in a warehouse for 3 months and the customer will say that one's better -- just based on the numbers.