No, not necessarily. Lots of people use it with great success. I personally don't have a lot of experience with soilless mediums. A transplant is in order, I would go with straight water for at least a week (maybe 1/4 strength Cal Mag as you are using Distilled Water). Let them get a little established in their new home and then bump up to 1/8 strength. You tried 1/4 strength and they went "ouch" so try 1/8 strength for a week, then go to a 1/4, then slowly bring it up from there. Generally I don't hit full strength until I'm about 1/2 way through flower.
Again, I don't usually grow in Pro Mix, so maybe someone else here will have some insight into starting strengths, but given your current situation this is the route that I would follow. It's important to also note that your old growth is now damaged, it will not return to its previous glory. When you have the problem solved the plant won't transform through magic back to a healthy looking plant right away. The new growth will come out nice and green and happy and the problems will stop spreading. That's how you know've you have resolved it.
Good luck, and I said, hopefully someone with ProMix experience can lend a little insight.