I use it only when i plan on inducing stress, or after stressing the plant. Transplanting, pruning, Supercropping, fimming..you get it. i use it as directed 1/4 tsp per gal. i dont foliar feed with it as i heard its contains somthing bad for foliar feed( axioms or something), i dont know if this is true but i kept it out of my routine. and as far as a differance i cant say either way cause im on my first real grow and have used it through out, but i can say that when i transplanted, and FIMMED my girls show no signs of stress and normal vigorous growth resumes withing 24-48 hours consistently. Also im planning on giving them one more treatment and cutting it out when i switch to flowering, as it will lengthen the flowering time, but i may continue to give it to one to see if its true and how significantly it extends flowering. Possibly give the buds a chance to pack on a few extra inchs, I dunno but we will see. Check my Grow Journal to see what im working on.