Compared to THC, which is a partial agonist at CB1 receptors, JWH-018 (and many of its analogues) are full agonists. This means that users may experience far more intense effects compared to smoking cannabis. THC has been shown to inhibit GABA neurotransmission in the brain via several pathways.[15][16] JWH-018 may cause intense anxiety, agitation, and even seizures or convulsions by inhibiting GABA neurotransmission more efficiently than THC. Cannabinoid receptor full agonists may present serious dangers to the user when overdosed.[17]