This was a reply on another forum to a siilar question.....
Yes it does. Its called curing. Only some of the THC forms while the plant is alive. If you smoke fresh cut greens its a major waste. It takes time for all the THC to form out of the moisture in the plant matter.
As it dries the THC developes a chrystaline structure called a trichome. Trying to dry it faster uses heat that degrades the molecular structure. Trying to freeze it may make it look like it is covered in trichomes, but the chrystals will form a different structure that degrades at room temperature and the structure will break down never forming THC. If it is already dry and cured, freezing can help preserve weed, but keeping it room temperature should do the same.
Think of fresh weed as having all the chemicals necessary to synthesize THC. Not until those ingredients are together under the right conditions will they react together to form the correct chemical structure. Those conditions happen to be dry, room temperature air that is changed out every day for several weeks until completely dry.
What I take from this is freezing isnt good, especially if like in my case the weed isnt cured yet.