The important aspect of cloning is that you retain the genotype of the plant, since mitois is involved in cell division the genotype is never lost from plant to clone, phenotype can change as environmental factor change. Only mutation of a gene in a vegetative cell that then divides and passes on the mutated gene will permanently affect the genotype of the clone. If this mutated portion is cloned or reproduced sexually, the mutant genotype will be further replicated. Mutations in clones usually affect dominance relations and are therefore noticed immediately.
clone selection and over cuttage of the mother plant can be a concern poor selection in clone sites will result in poor clones. With several clones grown together disease and pest affect all the clones since all the clone share the same genotype.
with all the seeds banks, the old school days of keeping mothers is coming to a close. Why keep a big mother plant when you can buy seeds with a guarantee of a stable genotype for several hundered strains.