I'm 59 and I have been partaking for 40 years. I work from home and smoke all day. I'm also a health nut. No sugar, preservatives, low blood pressure, etc. The restless leg and body result in extreme fatigue at around 7:30 pm every evening. When I smoke dispensary weed this doesn't happen at all. It only happens when I smoke my homegrown, which I have been harvesting way too early according to everything I have learned here.
There seems to still be a lot of unknowns. I am convinced that cannabis that is harvested too early has an adverse effect on anxiety, spasms, restless leg, and extreme fatigue. Just putting this out as it might be useful to someone who is doing a study one day.