I defoliate as I apply the LST. I am only on my second and third run of Autos and I take any leaves that are blocking potential top shoots. I have no idea that is good, bad or otherwise. I don't top them. My first run is starting to finish now and the results look promising. They could be better than they are but I identified lots of minor mistakes and corrected them, so these second and third runs should be better.
My main mistake was starting them off with a load of finishing photos on 12/12, the second and third runs are solely on 20/4. My other mistakes are based on my choice of medium, I tried a new medium which hasn't proven to be as good as I hoped, which led to deficiencies early on.