It could be the 1/2 strength nutes. Looks kinda like a big 3 micronute deficiency Cal, Mag or Iron. And/or Ph lockout, which would cause a deficiency as the nutes aren't made available to the plant.
On the Oddball, strange and unlikely front..... Do you have a Hops Vine??, or Does your jackass nieghbor have one???, or worse... did you bring one into the grow room too do a little re-fuckulate grafting experiment???? IF so, and IF the Hops looks like that, but 10 times worse.... it might be Septora. A disease that is not uncommon for Hops to have, and spread to its Cousins..