What nutes are you using? How well does it supply cannabis's needs? Are you using calmag? That plant looks beautiful! And happy! I don't think you have a big problem. If its only affected one leaf I wouldn't worry. The most I would do if I were in your shoes is flush no harm in it, flush with ph corrected water get the salts out then just go back to feeding like you we're. Purple stems should be caused from cold night. Your always gonna lose leaves you just have to know whether or not its natural or a problem and by the look of that plant I think It doesn't need that leaf anymore. I would be more afraid of over reacting and harming the plants health.