In that space my first run id probably run 4 plants and let them veg for a month so i could dial in the system.
And have time to read your strain and see how it reacts to nutes and light height, ph, temps, humidity.
Then when its lush green and growing healthy .... You may have hiccups...
Then flip it to flower once the space is filled out
That way you have lots of airflow down below . And youll have room to reach into the middle of your canopy . To get used to pruning and training.
Something tells me 16 plants your going to be overwhelmed
. Il follow ya, see how this grow turns out im interested to see a full on high effficiency grow first time