When the flowers are developing, the pistils (hairs) are all white for a while. I'd consider that the first flush. Then once most of the first flush have turned brown, some plants will put out a significant number of fresh white pistils, not nearly as many as the first flush but still noticeable (a second flush). Then as they mature, fresh white ones will keep slowly trickling in (not really a "flush" per se because it's not all at one time).
I'd wait at least until you're in that "trickling in" phase, when all the "original" hairs are brown. I would say wait until 100% of them are brown all over, but a lot of plants will keep spitting out a couple fresh ones here and there literally forever, so I just go by 100% of the initial one or two flushes