Thats a very vague question..
We need to know
Size of grow space
What strain/s
Grow medium being used
Time you plan to to veg them
If your only using a single plant for your grow then scroging will probably be best but if your running a few diferente varieties then you may want to top and train..
are your talking about pruneing popcorn buds off the bottoms of the branches when growing from clones?
as clone or plant would be the same.
never weighed my bud b4, so cant help on size per oz of weed