I'm on pristiq as well 100mg and really I've tested smoking on and off with the use of the medicine, and the best combination to keep my mood I guess happy is smoking and taking the pristiq, then for me at least just smoking is better then just taking pristiq, but I can't explain how much weed and pristiq has helped me this pass year, I definitely wouldn't be here without them. What pristiq will do is overtime reset the chemical imbalance in your brain, and then weed helps you get over those really tough moments, when you feel moments away from the end, smoking a bowl would immediately turn me from suicidal to loving life, modern medicine and organic methods is the perfect combination of medicine to me