Do a flush with PH'd water to begin with: hopefully will stop any overfeeding or potential PH issues then, start again with minimal nutes, if all else is on point they will recover, though damage won't be corrected, new growth should be good and you should see the issue recede
Incidentally, how early is early in flower ?!? I might advocate a heavy defoliation if plant was healthy, but a small one taking some older damaged leaves might not hurt and may help with vigour but not any later than week 3 of flower..
Maybe take just one or two from each cola, nothing major..
Lots will say don't, and there are reasons. But Its my humble opinion that this will begin to get your girls back on track.
Good luck.