I think short term it would just fucking destroy them. Power shifts, etc.
But what becomes their next gig? The ultimate goal is weapons and money and land, so they need a commodity to acquire those. It needs to be something that cost little to acquire, and sells for high dollar on the other end.
My bet is they ramp up human trafficking. Pot is an easy sell, I don't know if they could push other drugs successfully enough to replace their pot sales. But humans, either to fuck, torture, work or kill....there's never enough of those when you need them.