I use sulfur for leaf septoria, once you get you can only try to keep it at bay as long as possible. I have it again this year and I should have started spraying earlier. Once we get into flowering, I don't feel comfortable spraying sulfur. I also use Zerotol for powdery mildew, which can be sprayed right up to harvest, as there is no residue. Unfortunately, Zerotol has no effect on leaf septoria. I learned the hard way! I'm guessing that most plants will be harvested early, as the septoria gets on the sugar leaves eventually and then the buds get dead spots.