I'd go with a 6inch, too much heat will ruin the life span of your bulbs, make the weed smell travel farther, and if the heats too high you could get less potent/dense nugs(varying on the strain(even hermies if its too hot)). The 4" is only like 20bucks cheaper, so I'd put that 20bucks in for the 6" to make my grow room suitable for higher wattage bulbs in the future. By 6inch I mean exhaust fan, you want to also throw in regular cirulating fans to keep the air moving.