I personally like to defoliate. Once I flip to flower, I do all my lowers on the plant (normally around 1/4-1/3 of the plant depending on strain. After they stretch for a couple weeks I will go in and clean up the lowers one more time. At about week 3-4 of flower, I will start to remove a few of the larger fan leaves that are directly shading buds, and try to let a little more light in. Through out the grow as I notice large fan leaves that are directly shading buds or blocking a lot of light from getting in or overlapping fans, I will remove them. The last week, I will start to completely remove all the fans, a little bit each day until they are completely gone the day I harvest. I do this because it makes it easier when I harvest to separate the fans so when they dry and get trimmed, its all sugar leaf for extraction and the fans don't have to get separated from sugar while trimming. I also feel that opening up the plant by removing fans in the last week helps finish the plant off and finished the shaded buds in the middle better.
I have done an experiment where I did no defoliation on one side of the room and I did the other side how I explained above and I got 5oz more on the side I defoliated. It was a 6k room with the same cuts from the same mother on both sides of the room. I did this about 8 years ago so its been awhile. I get 2#+ per light regularly doing it this way.
Just my personal opinion and experience
This is a room that I defoliated like I described above. If you look closely there are not many fans left, if any at all.
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