Ime it can happen with unstable genetics as well, which there are a lot of being released ATM. Mutations/genetic drift in this sense happens much more often than natural/long term genetic drift/evolution lol.
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It is definitely true that a lot of unstable genetics are being passed around, but I think the term "unstable" is referring more to the multiple phenotypes than it does to genetic maladies.
If plants happened to mutate so frequently, don't you think we'd see a bunch of perennials that are all mutated and discombobulated after being alive for so many years? A cutting doesn't change the dna. It literally just causes roots to grow on a stem, which allows that piece of the original same plant, to sustain itself as a whole. IF you are doing something else to your clones, such as inducing extreme amounts of stress for many generations at a time, you MAY see a decline, but I'd honestly be hesitant to believe that if someone took a cutting of one of them and put it in ideal conditions, that it wouldn't grow perfectly healthy new growth, assuming there was no use of chemical growth regulators or mutagens, and also assuming that no plant virus was contracted at any point.
I have a "Calea Z." (not sure the actual identity) plant that grows really quickly, and roots faster than most other cuttings. I recently took a cutting (this week), and once I get it planted out and it has a bit of growth, I may start taking clones from that cutting, and the taking clones from those clones, until i get to 10-20 "generations", to see if anything is different than the mother plant. I may even grow some outside for a few generations, and some on a windowsill, to cause the most variance in genetic expression, and see if the next following generations show any impact, or if they revert back to how the mother looks when put back on the same shelf.