Lack of nitrogen [old growth first....] possibly due to rising pH. i had a similar problem in home-made soil. Thought I had plenty of Nitro, but the pH was a little higher than I liked and probably locked it out a bit and the plants couldn't uptake.....
I added N in small doses gradually. If this doesn't start helping the problem in just a few days, I will flush and start the cycle of low dose leading to "normal" doses of ferts, all over again.