You will find that as the biomass increases during stretch after flip the transpiration of moisture will increase a LOT. So your dehu may be unable to keep up with the demand. Generally by day 20 ish of 12/12 the plants kick into overdrive and they stay there until around day 50 ish (these numbers are for a 70 day strain and they do vary per strain). So if I am watering my plants every 24 hours on day 19 (soil is dry after 24 hours) then I will find myself having to water like every 12 hours when they start "peak drink" on day 20 ish. For those next 30 days the amount of water that needs to be removed from the air basically doubles. They speed up suddenly and they slow down suddenly. Remember that when they slow down if you keep watering at the high frequency, root rot is a likely result. I have had plants in 10 gallon pots go from taking 1.75 gallons every 24 hours speed up on day 20ish and require 1.75 gallons every 8 - 10 hours so thats even more than doubling the amount of moisture the dehu has to pull in a given time period. I ended up with three dehu's ( 2 x 100 pint and one 150 pint) in that room and still couldn't keep up with the RH% during lights out.
Lights out is when bad things happen RH wise. So lets say you are at 84F and 50% and the light go off. The AC stops fighting heat and thus doesn't pull any water, leaving it all on the dehu. The temps drop from 84F to lets say 75F, with a constant amount of moisture in the air this causes the RH% to spike to around 70% and to make matters worse the plants are still transpiring for about 20 minutes after lights out. So in this case you might see the RH% hitting 75 or 80% and thats no bueno. To make matters even worse, your dehumidifier is much less effective at pulling water out of the air when the air is cool. So you may be able to pull enough water when the air is warm but when it's cool the dehu struggles to pull half that amount. So this leaves us with one really big tool for this situation, a space heater. It will help prevent the night temp from dropping and raising the RH% on you and it will help the dehumidifier a great deal as air at 80F is much easier to dehu than air that is at 75F.