For my first grow I used Coco Coir and I must say it's been a pleasure to work with. I used 75% Coco and 25% Perlite, you can add more or take away depending on how often you want to water (take away Coco for more watering)
The great thing with coco is that it's dead easy to flush if you muck up on your nutes at any given point.
Just make sure you rinse it to get the excess salts out, although I'm pretty sure most companies do this now but doesn't hurt to check.
Also with Coco you measure you run off EC and if it's higher coming out than what you're putting in you're over feeding, if it's lower then increase your input by 0.2 EC, best advice anyone can give about coco.
At the end of the day all mediums differ but not by huge amounts if done correctly. Just choose which suits you best