i have a gut feeling that mixing strains in 1 SCRoG would be bad
for a start you wont know which is which, but 1 will stretch more than the other for sure
I wouldn't suggest mixing varieties until you have tried it a couple of times, but it can be done, I do it all the time.
The way I do it is that I screen it close to the bottom, and let it fill in until it's over 50% or so, then I let it grow another 16" or so, whenever it starts to get really uneven again, and then add a second screen. This time I fill 100% (or I try) of the holes, and flower as soon as the new screen is full. Any side branches that aren't used are cut along the way, and everything is kept well trimmed.
Once nice thing about it is that topping on the first screen doubles the bud sites, but topping on the second screen just makes the plant shorter.
At the end, I get 120-132 nice sized buds from a 2'x3' space with a 400 watt hps. I can get in six plants and end with bottom stems the size of my thumb.
Now it does have a couple of drawbacks...
1) It is labor intensive. I use it for relaxation, kinda like bonzai. Way too much work if that part isn't a way you have fun.
2) It adds a long time to the veg cycle.
So just to be clear, what I am talking about is basically SCROG->Lollypop (except to finish filling)->SCROG.
Works a champ for me, but like I said, I enjoy the gardening part.
I haven't seen anyone else write about this method, but its so simple I am sure I'm not the first to try.
Couple things to watch for:
Be generous in filling the first screen. The first time I did it, I thought 25% would be a good starting place for the first screen, but 60%-ish seems to be the best for the varieties I am growing.
Don't even think about trying this if your closet doesn't have ventilation, I haven't had any trouble with rot, but it packs a lot in a small space.
If I remember, I'll try to take a pic of my current grow, and post. Right now they are just starting to reach the second screen, so there isn't much to see yet, so it may be a while.
My light is vented, so I can put it very close to the plants, keep in mind that the whole point is to keep the shortest branch in enough light while keeping the tallest branch from getting too hot from the light. By SCROGging you even out the tops. By trimming-lollypopishly, you keep it under control (otherwise LOOKOUT), and then you SCROG to even out the tops for flowering.