VladFromOG
Active Member
So much thought lately goes into concentrating marijuana and the various tools used with the various forms of marijuana, but very little is seemingly given to the active compounds methods of action. This is a shame, because there are lots of things you can do to enhance and increase cannabis' effects in the body that are completely independent of the cannabis itself.
The cannabinoids are oxidized in the liver by the enzyme CYP 2C9 after they have circulated through the bloodstream. Inhibiting CYP 2C9 increases the duration and subjective potency of cannabis. There are a number of foods and OTC medications that can inhibit CYP 2C9 strongly:
CYP-29 Inhibitors
The antifungals Flucanazole and Miconazole (found in OTC jock itch preparation and in oral fast melt tabs by script)
Amentoflavone (found in Ginko biloba and St Johns Wort)
Quecertin (Weak inhibitor, flavone, found in your grocers supplement aisle and in low concentrations in most foods)
Piperine (Long/Black/West African Pepper)
What this means is that, for example, if you take half a gram of gingko or st johns wort, and wash it down with a 00 capsule full of ground african pepper, and a single dose of miconazole if you've got it, all about 30-45 minutes before you dose, you will need about 1/3 to 1/2 as much marijuana as you regularly do. Its surprising how well this works. Its especially handy if you dose orally - instead of getting relief for only an hour or two, an oral dose can last all day! By inhibiting this enzyme, you do make your initial experience a bit stronger, but where its really useful is in increasing the duration the cannabinoids are in your system. Its even useful if you smoke/vape your dose - instead of a half hour high, your steadily stoned for three, very handy when going out to the movies etc where you cant sneak away or light up.
Now, there is some risk with medication interaction anytime you inhibited liver enzymes, but the great thing is that, although CYP 2C9 is on of the all important Cytochrome P450 set, the inhibitors I list will not inhibit Cytochrome P450s, just CYP 2C9, which limits a lot of potential harmful interactions.
You can use any combo of the inhibitors I listed, the example I gave is just the easiest to acquire and my favorite combo. The african pepper, besides inhibiting CYP 2C9, also contains large amounts of beta-caryophyllene, which is a potent peripheral CB2 agonist, that has massive anti-inflammatory effects on its own, and really synergizes well with the pain killing effects of marijuana. Just be sure to grind the peppercorns yourself, the preground stuff has lost most of the goodies.
These simple, cheap supplements can really help you maximize your medication and boost its effectiveness as a pain killer. Hit up amazons supplement section, amd give it a try, you'll be amazed at how a $.25 cap of gingko and a $.05 cap of crushed african pepper can turn a single oral dose into an all day experience.
The cannabinoids are oxidized in the liver by the enzyme CYP 2C9 after they have circulated through the bloodstream. Inhibiting CYP 2C9 increases the duration and subjective potency of cannabis. There are a number of foods and OTC medications that can inhibit CYP 2C9 strongly:
CYP-29 Inhibitors
The antifungals Flucanazole and Miconazole (found in OTC jock itch preparation and in oral fast melt tabs by script)
Amentoflavone (found in Ginko biloba and St Johns Wort)
Quecertin (Weak inhibitor, flavone, found in your grocers supplement aisle and in low concentrations in most foods)
Piperine (Long/Black/West African Pepper)
What this means is that, for example, if you take half a gram of gingko or st johns wort, and wash it down with a 00 capsule full of ground african pepper, and a single dose of miconazole if you've got it, all about 30-45 minutes before you dose, you will need about 1/3 to 1/2 as much marijuana as you regularly do. Its surprising how well this works. Its especially handy if you dose orally - instead of getting relief for only an hour or two, an oral dose can last all day! By inhibiting this enzyme, you do make your initial experience a bit stronger, but where its really useful is in increasing the duration the cannabinoids are in your system. Its even useful if you smoke/vape your dose - instead of a half hour high, your steadily stoned for three, very handy when going out to the movies etc where you cant sneak away or light up.
Now, there is some risk with medication interaction anytime you inhibited liver enzymes, but the great thing is that, although CYP 2C9 is on of the all important Cytochrome P450 set, the inhibitors I list will not inhibit Cytochrome P450s, just CYP 2C9, which limits a lot of potential harmful interactions.
You can use any combo of the inhibitors I listed, the example I gave is just the easiest to acquire and my favorite combo. The african pepper, besides inhibiting CYP 2C9, also contains large amounts of beta-caryophyllene, which is a potent peripheral CB2 agonist, that has massive anti-inflammatory effects on its own, and really synergizes well with the pain killing effects of marijuana. Just be sure to grind the peppercorns yourself, the preground stuff has lost most of the goodies.
These simple, cheap supplements can really help you maximize your medication and boost its effectiveness as a pain killer. Hit up amazons supplement section, amd give it a try, you'll be amazed at how a $.25 cap of gingko and a $.05 cap of crushed african pepper can turn a single oral dose into an all day experience.
-THC, and the 9alpha,10alpha-epoxidation of Delta(9)-THC.
