What poop said...check runoff ppm.
Looks like it could be related to K. I agree, too much dryback can cause nutes in media to be out of balance.
What PPM / EC are you feeding? PH? Anything else besides Jacks 321 in the res?
Feeding more volume, with more runoff, pushes out the old, and brings in the new balanced nutes.
This is the best link I have...