If you are 100% sure, REMOVE THEM NOW.
But if you are a beginner at growing, which you undoubtedly are, you are more inclined to mistaking a slow developing female for a male. I've done it. We've all done it.
If you just started flowering though, you do have a grace period, roughly 10-14 days. Then the first few pollen sacs will open and fertilize those few virgins you do have. Not a good thing.
But if you're 100% sure, as in you see little apples-on-a-stick doubling up around the nodes, remove em.