How old are the plants? What soil? What nutrients are you using? How much nutrients are you using? What's the PPM of the water after you've mixed in your nutrients? What is the pH of your water and water nutrient mix? What signs do you see that tells you that you're over-fertilizing?
How about some pics (with the grow lights turned off)?
For starters, with a water source of less than 200-250, you typically want to be sure to be using a Calcium and Magnesium supplement (eg. Botanicare Cal-Mag Plus).