Switching Strains, New High Tolerance?

I have a tolerance question for experienced users.

A friend of mine uses MJ medicinally for anxiety. He says he only buys about 1/8 of an ounce at a time and changes strains every purchase because it helps keep his tolerance down. He says he has two tolerances, one tolerance to weed in general and another tolerance that's specific to whatever strain he's been smoking lately.

What do ya'll think, have you noticed the same thing? If you use the same strain for a long period of time and switch to another is your tolerance effected? Have you developed a stronger tolerance for one regularly used strain then for another, less frequently used strain?

Of course. Your brain gets too familiar with a strain if you use it for too long.

I like to keep three or four different strains on hand to combat this.

yeah some strains develop tolerance very very easily.

I have no idea why a different strain exactly gets you high again. I would think any over-exposure to cannabinoids would tire your cannabinoid receptor out to the point of tolerance to all pot.

actually, that's how I was for a while, nothing would get me high. new strains would only phase me slightly more than the stuff I had been smoking before.

essentially if you don't need it for something major like anxiety, you need to conserve and control your tolerance .

Good lordy, you guys are fast!

motorboater, so you've noticed if you mix it up with a few different strains it's enough? You don't need to move onto a completely different strain every so often, just a little variety will suffice?

poplars said:

I would think any over-exposure to cannabinoids would tire your cannabinoid receptor out to the point of tolerance to all pot.

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Interesting point. Maybe with a change in strains the change in concentration of all the various psycho-active compounds effects different receptors, like driving on a freshly paved road versus driving the same old pot-hole ridden road.

vh13 said:

Good lordy, you guys are fast!

motorboater, so you've noticed if you mix it up with a few different strains it's enough? You don't need to move onto a completely different strain every so often, just a little variety will suffice?

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Well I move on to competely different strains a couple times a month, so i cant really comment there. But yes, mixing it up helps. The brain seems to get adjusted to the ratio's of THC and CBD, so by changing it up often you're not developing a tolerance to just one strain.

For example, I've been doing LA Confidential every day this week. On my first day, one balloon of vapor got me absolutely wrecked. As of yesterday, the high has calmed down to normal.

technically, each strain of cannabis has their own set scale of cannabinoids, and there are almost 60 different known cannabinoids in weed. and its not just the cannibinoid compound "THC" that is psychoactive in weed, all cannabinoids effect in some form or another. and since each strain has their own unique set of cannabinoids, it stimulates differently than others would. right??

im no scholar or anything. i have taken a single botany course which cant call for alot lol. so please correct me if im wrong on this.

hope all this makes sense, im really blazed off that white berry. one love yall

Farmer Pat said:

technically, each strain of cannabis has their own set scale of cannabinoids, and there are almost 60 different known cannabinoids in weed. and its not just the cannibinoid compound "THC" that is psychoactive in weed, all cannabinoids effect in some form or another. and since each strain has their own unique set of cannabinoids, it stimulates differently than others would. right??

im no scholar or anything. i have taken a single botany course which cant call for alot lol. so please correct me if im wrong on this.

hope all this makes sense, im really blazed off that white berry. one love yall

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I also stumbled upon the idea that we probably have more than 2 different kinds of cannabinoid receptors.

a receptor that would explain tolerance to weed in general, and a receptor that would explain tolerances to different kinds of weeds, etc. and then receptors to explain how a new kind of weed will effect us like we hadn't smoked in years . . . .

plants + chemical development + our own elegant yet largely misunderstood chemical system in our brain = bliss.

I build up a tolerance when I smoke the same strain for a while.. Especially since I'm a daily smoker. I always have 3 or 4 different kinds of weed at a time so that I dont build up a tolerance to a specific one. I pretty much switch up what I smoke on a daily basis.

Wow, what an old thread. Ya'll brought it back from the dead. Thanks for stopping by.

Since my original post, I've observed the same as ya'll. Right now, I usually get 2-3 different strains every week, the good ones get more replay.