It's pretty dangerous, truth be told. Lye is no joke, and the naptha is extremely flammable. Make sure the container can't be corroded by the lye, and make sure to use the naptha outside. Even if it doesn't blow up, it stinks super duper bad. You might not be able to find Naptha depending on where you live, but I'm sure there are other solvents you can use.
No, I never worried about ayahuasca. DMT is insanely powerful and I wouldn't want to trip on it more than a few minutes. I'm sure it's pretty easy if you can find the whatever vine they use.