How Do I Connect to HVAC?

My new grow room is right next to the HVAC system for the building. The main exhaust duct is right there, so I plan to connect my exhaust fans to the ducts.
Is there another way I should do it? Can I utilize the HVAC system to help ventilate?

You can cut a hole right before wher you replace the filter, that's before the fan in the central unit...

But the circulation of return air from the house will be compromised.