That's because the answer is yes...and no. Enzymes and other micro life work great and are a huge part of how plants uptake nutrients in the natural world. Synthetic nutrients are all salt based so these salts will build up in your soil. Some worse than others.
These salts will kill all of your micro flora and fauna. It takes time, but it will happen. So I guess the best I can tell you is that they will work - until you kill them.