I have moms in 5 gal dwcs, been going for 6+ months now. I don't have any issues, top up every other day or so with RO or a weak nute mix depending on what they are doing. I do a complete change out every 2 weeks, or when i start to see lower leaf changes. Bigger res will mean less maintenance. My 5 gals hold about 3 gals of solution with a root ball taking up half the bucket. I grow them Bonsai style, keep em short and trimmed, both moms are wider than the bucket but under 12" tall, both moms have well over 30 tops/ clone sites on them. I plan on replacing the moms once a year from cuttings and then I'll flower out the old mom. I'd like to eventually have a 4-6 site rdwc system for moms.
I haven't root pruned my dwc plants, but I've done soil plants. I'm no expert but I only remove about an inch around the ball( 2" total off the dia.) and 1" off the bottom. In soil I loosen up the root ball before replanting..don't think it will matter in DWC.