There's no reason for speed/crank/meth. You legalize it, you should also legalize killing tweakers. I had a child once. That child was taken from me by a tweaker. It was the bitch from who's cunt my child was spat. She used crank. Thats "oldschool meth" or "biker's meth." I enjoy meth users, dealers, and especially cooks... But, my pleasure with them (and subsequent disposal) are no more legal than the poison that they concoct and sell.
Heroin used to be legal, and marketed by Bayer. Cocaine, it had a run on the shelves, and was a key ingredient in a "soft drink" made by a company from the ATL.
Marijuana is illegal for one reason. Racism. That is it. This country was built on Hemp and Sativa. Our founding fathers thought that "every free man should be compelled, if he doesn't voluntarily do it, to grow at least 1 acre of Hemp each year." But, it was something that was commonly shared by 3 groups, in the early 20th century: Native Americans/First Nations/Indigenous trbes, Mexicans/Spaniards, and African Americans. It's the last true Jim Crow law that needs to be repealed.
All said -- you think synthetics should be legal, I think my kind should be allowed to live out our natures... Otherwise, control synthetic/manufactured/processed chemicals, and leave plants the fuck alone. (I.e. Coca leaves are groovy, cocaine puts you on my "I'm bored, what can I cut" list. Peyote or shrooms will help you with enlightenment, heroin and meth guarantee me the right to correct any wrongs, flesh for flesh, that you do.)